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J Struct Biol. 1997 Jul;119(2):165-71.

Probing single biomolecules with atomic force microscopy.

Author information

1
Scientific Services, Physics, Novartis Services AG, Basel, Switzerland.

Abstract

During the last years, atomic force microscopy (AFM) has developed from a microscopy tool for solid-state surface science toward a method employed in many scientific disciplines, such as biology, for investigating individual molecules on a nanometer scale. This article describes the current status of the imaging possibilities of AFM on RNA, IgG, and gold-labeled cell adhesion proteoglycans, as well as of measurements of intermolecular binding forces between biomolecules in order to investigate their molecular structure, function, and elasticity.

PMID:
9245757
DOI:
10.1006/jsbi.1997.3887
[Indexed for MEDLINE]

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