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Neuroreport. 1997 Jul 7;8(9-10):2155-8.

Beta APP gene transfer into cultured human muscle induces inclusion-body myositis aspects.

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Department of Neurology, University of Southern California, School of Medicine, Good Samaritan Hospital, Los Angeles 90017-1912, USA.


Direct transfer of the beta-amyloid precursor protein (beta APP) gene into cultured normal human muscle, using recombinant adenovirus vector, was sufficient to induce several of the typical light microscopic, electron microscopic (EM), and EM-immunochemical aspects of the inclusion-body myositis (IBM) phenotype, including congophilia, clusters of amyloid-beta-positive 6-10 nm filaments, and 15-21 nm tubulofilamentous inclusions in the nuclei. Our results suggest that excessive production of intracellular beta APP may play an important role in the pathogenic cascade leading to the IBM phenotype.

[Indexed for MEDLINE]

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