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Clin Infect Dis. 1997 Jul;25(1):149-51.

Minocycline and ethylenediaminetetraacetate for the prevention of recurrent vascular catheter infections.

Author information

1
Department of Medical Specialties, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.

Abstract

Three patients with recurrent vascular catheter-related bacteremia were successfully treated by allowing a solution of minocycline and ethylenediaminetetraacetate (EDTA) to dwell in the lumen of the indwelling catheter or by coating polyurethane catheters with minocycline/EDTA and flushing the lumen daily with the same solution. In vitro and in vivo experiments showed that minocycline/EDTA may have broad-spectrum antimicrobial activity, may have optimal anticoagulant activity, and may be highly efficacious in preventing catheter colonization.

PMID:
9243049
DOI:
10.1086/514518
[Indexed for MEDLINE]

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