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Acta Anaesthesiol Scand. 1997 Jun;41(6):746-9.

Granisetron reduces incidence of nausea and vomiting after breast surgery.

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  • 1Department of Anaesthesiology, Toride Kyodo General Hospital, Ibaraki, Japan.

Abstract

BACKGROUND:

Postoperative nausea and vomiting (PONV) remains a troublesome problem. The study was performed to evaluate the antiemetic efficacy of prophylactic granisetron, a selective 5-hydroxytryptamine type 3 receptor antagonist, on the incidence of PONV in patients undergoing general anaesthesia for breast surgery.

METHODS:

In a randomized, placebo-controlled, double-blind study, 50 female patients, 45-68 years, were given a single dose of either placebo (saline, n = 25) or granisetron (40 micrograms.kg-1, n = 25) intravenously over 2-5 min immediately before the induction of anaesthesia. Postoperatively, during the first 24 hours after anaesthesia, the incidence of PONV and adverse events was recorded.

RESULTS:

The treatment groups were similar for patient demographics, types of surgery, anaesthetic and postoperative management. Postoperatively, the incidence of PONV was 48% and 16% after administration of placebo and granisetron, respectively (P < 0.05). No differences in the incidence of other adverse events were observed between the two groups.

CONCLUSION:

Granisetron is an effective antiemetic for preventing PONV in patients undergoing general anaesthesia for breast surgery.

PMID:
9241336
[PubMed - indexed for MEDLINE]
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