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Am J Obstet Gynecol. 1997 Jul;177(1):57-65.

Placental apoptosis in normal human pregnancy.

Author information

1
University Department of Obstetrics and Gynaecology, University of Nottingham, City Hospital, United Kingdom.

Abstract

OBJECTIVES:

The study aims were to conclusively demonstrate apoptosis in the human placenta and to quantify its incidence at different stages of pregnancy.

STUDY DESIGN:

Placental samples were obtained from 28 first-trimester pregnancies and 38 uncomplicated third-trimester pregnancies. Light microscopy, electron microscopy, and terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate marker nick end-labeling staining were used to identify apoptosis. Light microscopy was used to quantify its incidence.

RESULTS:

Apoptosis has been conclusively demonstrated within placental tissue. Quantification of apoptosis (medians and interquartile ranges) was as follows: first trimester (n = 28), 0.07% of cells (0.05% to 0.14%); third trimester (n = 39), 0.14% of cells (0.09% to 0.20%). The incidence of apoptosis was significantly higher in the third trimester than in the first trimester (p < 0.01, Mann-Whitney U test).

CONCLUSIONS:

Placental apoptosis increases significantly as pregnancy progresses, suggesting that it may play a role in the normal development and aging of the placenta.

PMID:
9240583
DOI:
10.1016/s0002-9378(97)70438-1
[Indexed for MEDLINE]

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