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J Vasc Surg. 1997 Jul;26(1):29-31.

Detection of Chlamydia pneumoniae in atherosclerotic plaques in the walls of arteries of lower extremities from patients undergoing bypass operation for arterial obstruction.

Author information

1
Department of Pathobiology, University of Washington, Seattle 98195, USA.

Abstract

PURPOSE:

To study surgically excised vascular tissue from lower extremities for the presence of Chlamydia pneumoniae, to extend the previously described association of the organism with atherosclerosis.

METHODS:

Arterial biopsy specimens obtained from femoral and popliteal arteries during bypass operation for claudication were examined by immunocytochemical analysis and polymerase chain reaction for the presence of organisms.

RESULTS:

C. pneumoniae was detected in atherosclerotic plaques by either method in either artery of 11 of 23 patients (48%). Eight of 21 popliteal and three of 18 femoral arteries had positive results.

CONCLUSIONS:

Detection of C. pneumoniae in peripheral arteries indicates that the organism is widespread in atherosclerosis of the vascular system.

PMID:
9240318
DOI:
10.1016/s0741-5214(97)70143-5
[Indexed for MEDLINE]
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