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Semin Immunol. 1997 Aug;9(4):261-8.

B-cell activation and development within chronically inflamed synovium in rheumatoid and reactive arthritis.

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Deutsches Rheuma ForschungsZentrum, Berlin Monbijoustr. 2, Berlin, 10117, Germany.


In autoimmune diseases, B cells often accumulate in the affected tissue. In patients with rheumatoid arthritis or reactive arthritis, germinal center-like structures may develop in the inflamed synovial tissue. B cells from these structures were isolated and their V-gene repertoire determined. The majority of synovial B cells are long-term memory cells and thus are part of the chronic inflammatory reaction. In the synovium a micro-environment is built up which allows the activation of naive and memory B cells and the diversification of their V-gene repertoire. The analysis of plasma cells suggests that these cells are long lived and hence accumulate in the synovial tissue under chronic activation.

[Indexed for MEDLINE]

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