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Arch Neurol. 1997 Jul;54(7):862-4.

Role of antiribosomal P protein antibodies in the diagnosis of lupus isolated to the central nervous system.

Author information

1
Department of Neurology, University of California, Davis, USA.

Abstract

BACKGROUND:

When lupus presents with isolated central nervous system findings, the usual serologic markers are often absent and diagnostic difficulty with a delay in treatment is common.

OBJECTIVE:

To report the usefulness of antiribosomal P protein antibodies in the diagnosis of lupus isolated to the central nervous system when results of tests for anti-double-stranded DNA antibodies are negative.

DESIGN:

Case report.

SETTING:

University medical center.

PATIENT:

The patient was evaluated and treated on referral and follow up for 1 year.

RESULTS:

We describe a patient with acute onset of psychosis followed by coma and focal clonic movements with undetectable DNA antibodies. Serum antiribosomal P protein antibody levels were elevated. Steroid therapy was followed by marked clinical improvement and a decrease in antibody titer.

CONCLUSION:

Antiribosomal P protein antibodies provide an important confirmatory test for the diagnosis of lupus isolated to the central nervous system when results of tests for anti-double-stranded DNA antibodies are negative.

[Indexed for MEDLINE]

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