Format

Send to

Choose Destination
See comment in PubMed Commons below
Biologicals. 1997 Jun;25(2):205-8.

Changes in the aging immune system.

Author information

  • 1Institute for Biomedical Aging Research, Austrian Academy of Sciences, Innsbruck, Austria.

Abstract

The functional capacity of the immune system gradually declines with age. T lymphocytes are more severely affected than B cells or antigen-presenting cells. This is mainly due to the involution of the thymus which is almost complete at the age of 60. The host is then dependent on the T cell pool generated in earlier life. Continuous activation, clonal expansion and elimination of T cells of various specificities eventually leads to changes in the T cell repertoire. CD45RA+ "naive" cells are replaced by CD45RA- "memory" cells and a T cell receptor oligoclonality develops. At the same time, T cells with signal transduction defects accumulate. Age-related T cell alterations lead to a decreased clonal expansion and a reduced efficiency of T cell effector functions such as cytotoxicity or B cell help. Decreased antibody production and a shortened immunological memory are the consequence. Changes in the aging immune system represent a permissive factor for the frequent occurrence and the severity of disease. Efficient protection of elderly individuals by suitable vaccination strategies is therefore a matter of great importance.

PMID:
9236053
DOI:
10.1006/biol.1997.0085
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center