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Chem Biol. 1997 Apr;4(4):249-57.

Essential biochemical design features of the fuel-sensing system in pancreatic beta-cells.

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Diabetes Research Center, University of Pennsylvania School of Medicine, 501 Stemmler Hall, 36th and Hamilton Walk, Philadelphia, PA 19104-6015, USA.


The beta-cells of the pancreas control the blood levels of glucose and other nutrients by secreting insulin. They sense blood nutrient levels not by using a classical receptor-signaling system, but by detecting the products of nutrient metabolism. Mutations in this pathway can cause diabetes or hypoglycemia.

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