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Infect Immun. 1997 Aug;65(8):3469-73.

Phase variation affects long-term survival of Bordetella bronchiseptica in professional phagocytes.

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  • 1Lehrstuhl für Mikrobiologie, Theodor-Boveri-Institut, Biozentrum der Universität Würzburg, Germany.

Abstract

Several Bordetella bronchiseptica isolates were investigated for intracellular survival in macrophages. A significant number of viable bacteria of all strains could be recovered even after 96 h postinfection. In all cases bvg mutants of the B. bronchiseptica strains showed a significant survival advantage over the respective wild-type strains. The bacteria were already located in phagolysosomes early after uptake. Neither opsonization of the bacteria nor activation of the macrophages with gamma interferon or lipopolysaccharide prior to infection affected uptake and survival of the bacteria.

PMID:
9234815
PMCID:
PMC175492
[PubMed - indexed for MEDLINE]
Free PMC Article
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