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Trends Microbiol. 1997 Jul;5(7):288-93.

Origins and functions of the chlamydial inclusion.

Author information

1
Host-Parasite Interactions Section, National Institute of Allergy and Infections Diseases, NIH, Rocky Mountain Laboratories, Hamilton, MT 59840, USA. tedvhackstadt@nib.gov

Abstract

Chlamydiae dissociate themselves from the endocytic pathway shortly after internalization by actively modifying the vacuole to become fusogenic with sphingomyelin-containing exocytic vesicles. Interaction with this secretory pathway appears to provide a pathogenic mechanism that allows chlamydiae to establish themselves in a site that is not destined to fuse with lysosomes.

PMID:
9234512
DOI:
10.1016/S0966-842X(97)01061-5
[Indexed for MEDLINE]

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