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Trends Microbiol. 1997 Jul;5(7):282-8.

Rho proteins: targets for bacterial toxins.

Author information

1
Institut für Pharmakologie and Toxikologie, Albert-Ludwigs-Universität Freiburg, Germany. aktories@ruf.uni-freiburg.de

Abstract

GTP-binding proteins of the Rho family are regulators of the actin cytoskeleton and molecular switches in various signal transduction pathways. The Rho proteins are targets for bacterial protein toxins that either inactivate GTPases by ADP-ribosylation or glucosylation, or activate them by deamidation. Rho proteins play essential roles in host cell invasion by bacteria.

PMID:
9234511
DOI:
10.1016/S0966-842X(97)01067-6
[Indexed for MEDLINE]

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