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Curr Opin Neurobiol. 1997 Jun;7(3):419-29.

Ca2+-dependent regulation in neuronal gene expression.

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Department of Pharmacology, Kyoto University Faculty of Medicine, Sakyo-ku, Kyoto 606-01, Japan.


Ca2+ is an important signal-transduction molecule that plays a role in many intracellular signaling pathways. Recent advances have indicated that in neurons, Ca2+-controlled signaling mechanisms cooperate in order to discriminate amongst incoming cellular inputs. Ca2+-dependent transcriptional events can thereby be made selectively responsive to bursts of synaptic activity of specific intensity or duration.

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