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Curr Opin Neurobiol. 1997 Jun;7(3):339-45.

The InsP3 receptor and intracellular Ca2+ signaling.

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Department of Molecular Neurobiology, Institute of Medical Science University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108, Japan.


The inositol 1,4,5-trisphosphate receptor (InsP3R) is a ligand-gated Ca2+-release channel on intracellular Ca2+ store sites (such as the endoplasmic reticulum), and plays an important role in intracellular Ca2+ signaling in a wide variety of cell types. Recent studies have shown that binding of inositol 1,4,5-trisphosphate (InsP3) to InsP3R isoforms is differentially regulated by Ca2+, and that InsP3R functions are finely regulated by phosphorylation via tyrosine kinases and protein kinase C, by dephosphorylation via calcineurin, and by binding to FKBP (FK506-binding protein). In addition, transient receptor potential (TRP) and TRP-like proteins appear to couple conformationally with the InsP3R for capacitative Ca2+ entry. The importance of InsP3R signaling in neuronal function has been demonstrated by gene targeting in mice and by studies of T-cell receptor signaling, apoptosis, meiotic maturation, and cytokinesis.

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