Three-dimensional structures and contexts associated with recurrent amino acid sequence patterns

K F Han; C Bystroff; D Baker

doi:10.1002/pro.5560060723

Three-dimensional structures and contexts associated with recurrent amino acid sequence patterns

Protein Sci. 1997 Jul;6(7):1587-90. doi: 10.1002/pro.5560060723.

Authors

K F Han¹, C Bystroff, D Baker

Affiliation

¹ Graduate Group in Biophysics, University of California San Francisco School of Medicine 94143-0448, USA.

Abstract

We have used cluster analysis to identify recurring sequence patterns that transcend protein family boundaries. A subset of these patterns occur predominantly in a single type of local structure in proteins. Here we characterize the three-dimensional structures and contexts in which these sequence patterns occur, with particular attention to the interactions responsible for their structural selectivity.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Algorithms
Amino Acid Sequence*
Cluster Analysis*
Databases, Factual
Pattern Recognition, Automated*
Protein Conformation*
Sequence Alignment