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Lab Anim. 1997 Jul;31(3):231-40.

Method for long-term intestinal access in the dog.

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Laboratory Animal Resources, Astra Hässle AB, Mölndal, Sweden.


A variety of devices have been used to establish long-term intestinal access in laboratory animals. Their use is complicated by infection, tissue reaction, and a frequent need for single housing to prevent implant damage. Intussuscepted nipple valves have long been used in the human field of surgery for various applications where there is a need to create a reservoir without leakage. With the use of the nipple valve it was possible to establish long-term intestinal access in dogs with minimal post-operative complications, no leakage and, because no foreign material was used, no complications due to tissue rejection. The advantages of a nipple valve over the similar technique of a straight stoma is less postoperative complications in the form of leakage as well as enhanced access due to the design of the nipple valve. Encouraging results prompted us to widen the use of nipple valves to 14 dogs in which it has been possible to establish long-term colonic or duodenal/ileal access at one or two sites. Nine of the dogs are still in use with duration of instrumentation for some animals exceeding 60 weeks. This method requires minimal maintenance, does not prevent group housing of instrumented dogs or outdoor activities nor does it compromise the quality of life for the animals.

[Indexed for MEDLINE]

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