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Curr Opin Genet Dev. 1997 Jun;7(3):345-53.

RNA-binding proteins as regulators of gene expression.

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Howard Hughes Medical Institute, University of Pennsylvania School of Medicine Philadelphia 19104-6148, USA.


A plethora of post-transcriptional mechanisms are involved in essential steps in the pathway of genetic information expression in eukaryotes. These processes are specified by cis-acting signals on RNAs and are mediated by specific trans-acting factors, including RNA-binding proteins and small complementary RNAs. Recent information has begun to define the molecular mechanisms by which RNA-binding proteins recognize specific RNA sequences and influence the processing and function of RNA molecules.

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