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Nat Struct Biol. 1997 Jul;4(7):527-31.

Solution structure of human CTLA-4 and delineation of a CD80/CD86 binding site conserved in CD28.

Abstract

The structure of human CTLA-4 reveals that residues Met 99, Tyr 100 and Tyr 104 of the M99YPPPY104 motif are adjacent to a patch of charged surface residues on the A'GFCC' face of the protein. Mutation of these residues, which are conserved in the CTLA-4/CD28 family, significantly reduces binding to CD80 and/or CD86, implicating this patch as a ligand binding site.

PMID:
9228944
DOI:
10.1038/nsb0797-527
[Indexed for MEDLINE]

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