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FEMS Microbiol Lett. 1997 Jul 1;152(1):163-7.

Substitution of alanine for aspartate at position 179 in the SHV-6 extended-spectrum beta-lactamase.

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Université Paris VII Denis Diderot, Service de Microbiologie, Hôpital Saint-Louis, Paris, France.


SHV-6 was previously identified by its susceptibility pattern and biochemical criteria in a clinical isolate of Klebsiella pneumoniae which was resistant to ceftazidime. It contains only a single point difference with the beta laSHV-1 gene as determined by PCR amplification and nucleotide sequencing. This is the result of a single amino acid substitution, Ala for Asp, at position 179. Directed mutagenesis experiments have shown this substitution to confer selective resistance to ceftazidime in the TEM family.

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