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Science. 1997 Jul 25;277(5325):559-62.

Bcl-2: prolonging life in a transgenic mouse model of familial amyotrophic lateral sclerosis.

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Department of Neurology, Columbia University, 650 West 168 Street, BB-307, New York, NY 10032, USA.


Mutations in the gene encoding copper/zinc superoxide dismutase enzyme produce an animal model of familial amyotrophic lateral sclerosis (FALS), a fatal disorder characterized by paralysis. Overexpression of the proto-oncogene bcl-2 delayed onset of motor neuron disease and prolonged survival in transgenic mice expressing the FALS-linked mutation in which glycine is substituted by alanine at position 93. It did not, however, alter the duration of the disease. Overexpression of bcl-2 also attenuated the magnitude of spinal cord motor neuron degeneration in the FALS-transgenic mice.

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