Format

Send to

Choose Destination
See comment in PubMed Commons below
Eur J Pharmacol. 1997 Jun 25;329(2-3):129-32.

Chronic zolpidem treatment alters GABA(A) receptor mRNA levels in the rat cortex.

Author information

1
Department of Pharmacology, University of Alberta, Edmonton, Canada.

Abstract

The effect of chronic zolpidem treatment on the steady-state levels of gamma-aminobutyric acidA alpha1-6, beta1-3 and gamma1-3 subunit mRNAs in rat cortex has been investigated. Male Sprague-Dawley rats were injected once daily, for 7 or 14 days, with 15 mg/kg of zolpidem in sesame oil vehicle. The levels of the alpha4 and beta1 subunit mRNAs were significantly increased after 7 days of treatment and the level of alpha1 subunit mRNA was significantly decreased after 14 days of treatment, as determined by solution hybridization. These results are compared to the previously determined effects of an equivalent schedule of treatment with diazepam.

PMID:
9226404
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center