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Gene. 1997 Jun 11;192(1):135-40.

Microevolution and epidemic spread of serogroup A Neisseria meningitidis--a review.

Author information

1
Max-Planck-Institut für molekulare Genetik, Berlin, Germany. achtman@mpimg-berlin-dahlem.mpg.de

Abstract

An extensive and representative strain collection of serogroup A Neisseria meningitidis was established. These bacteria were obtained from different endemic and epidemic/pandemic sources and include strains from diseased patients and healthy carriers. The genetic relationships of the bacteria were defined by multi-locus enzyme electrophoresis and sequence polymorphisms of genetically variable antigens have been analyzed in closely-related groupings. The results are interpreted as reflecting a balance of recombination events, which disrupt clonal relationships, and sequential bottlenecks, which purify the bacterial population of genetic variants during epidemic spread.

PMID:
9224883
DOI:
10.1016/s0378-1119(97)00083-8
[Indexed for MEDLINE]

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