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FEBS Lett. 1997 Jun 16;409(3):325-32.

The complete inventory of the yeast Saccharomyces cerevisiae P-type transport ATPases.

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1
Unité de Biochimie Physiologique, Université Catholique de Louvain, Louvain-La-Neuve, Belgium.

Abstract

A total of sixteen open reading frames encoding for P-type ATPases have been identified in the complete genome sequence of Saccharomyces cerevisiae. Phylogenetic analysis distinguishes 6 distinct families. Topology predictions, identification of aminoacid sequence motifs and phenotype analysis of the available mutants suggest that these families correspond to ATPases transporting either H+ (2 members), Ca2+ (2 members), Na+ (3 members), heavy metals (2 members), possibly aminophospholipids (5 members including 4 new ones) or unknown substrates (2 new members). It is proposed that the latter family which has homologs in Tetrahymena thermophila, Plasmodium falciparum and Caenorhabditis elegans constitutes a new group called P4-ATPases with characteristic topology and aminoacid signatures.

PMID:
9224683
[Indexed for MEDLINE]
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