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Biochem Biophys Res Commun. 1997 Jul 9;236(1):75-8.

A novel fungal gene encoding chitin synthase with a myosin motor-like domain.

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Department of Biotechnology, The University of Tokyo, Bunkyo-ku, Japan.


A csmA gene that encodes chitin synthase with a myosin motor-like domain was isolated from the filamentous fungus Aspergillus nidulans. Initially, we obtained the csmA as a homolog of the Aspergillus fumigatus chsE-partial fragment. A large open reading frame encoding a polypeptide of 1,852 a.a. was identified by determining the cDNA sequences. The chitin synthase conserved region was situated at the C-terminus and classified into class V as reported previously. On the other hand, the N-terminal region showed significant similarity to myosin motors and could not be classified into any types of myosins identified so far. Thus, it is suggested that this is the first report of unconventional myosin fused to a metabolic enzyme. The finding of this new type of chitin synthase gene suggests that localization of chitin synthesis may be guided by association with cytoskeletal structures.

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