Format

Send to

Choose Destination
Trends Neurosci. 1997 Jul;20(7):287-90.

p75NTR and apoptosis: Trk-dependent and Trk-independent effects.

Author information

1
Burnham Institute, La Jolla, CA 92037, USA.

Abstract

The ongoing dissection of the roles of p75NTR and TrkA, -B and -C in neurotrophin signaling has generated a number of apparent paradoxes. Limiting consideration to the role of p75NTR in cell death, a theory is proposed that is based on the following postulates: (1) that p75NTR displays a pro-apoptotic intrinsic (ligand-independent, Trk-independent) receptor effect (IRE), which is inhibited by ligand binding; (2) that p75NTR and TrkA exhibit mutual repression of signaling; and (3) that p75NTR and TrkA are required for the efficient generation of high-affinity NGF binding sites.

PMID:
9223218
DOI:
10.1016/s0166-2236(96)01049-1
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center