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Mol Microbiol. 1997 Jun;24(5):905-15.

The Bacillus subtilis DivIVA protein targets to the division septum and controls the site specificity of cell division.

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Sir William Dunn School of Pathology, University of Oxford, UK.


The Bacillus subtilis divIVA gene, first defined by a mutation giving rise to anucleate minicells, has been cloned and characterized. Depletion of DivIVA leads to inhibition of the initiation of cell division. The residual divisions that do occur are abnormally placed and sometimes misorientated relative to the long axis of the cell. The DivIVA phenotype can be suppressed by disruption of the MinCD division inhibitor, suggesting that DivIVA controls the topological specificity of MinCD action and thus septum positioning. A DivIVA-GFP fusion targets to new and used sites of cell division, consistent with it having a direct role in topological specification.

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