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Brain Res. 1997 Jun 6;759(1):160-2.

OFF pathway is preferentially suppressed by the activation of GABA(A) receptors in carp retina.

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  • 1Shanghai Institute of Physiology, Chinese Academy of Sciences.

Abstract

This study examines the effect of gamma-aminobutyric acid (GABA) on the ON and OFF pathways in isolated, superfused carp retina. In most (76%) of amacrine cells bath-applied GABA preferentially suppressed the OFF response. The effect of GABA was blocked by bicuculline. Baclofen did not cause a similar effect. Furthermore, GABA produced a substantial suppression of the OFF bipolar cell response. We conclude that the preferential suppression of the OFF pathway may be due to a presynaptic inhibition mediated via GABA(A) receptors at the terminals of OFF bipolar cells.

PMID:
9219876
[PubMed - indexed for MEDLINE]
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