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Pharmacol Biochem Behav. 1997 Jul;57(3):449-55.

Sensitization to the behavioral effects of cocaine: modulation by dynorphin and kappa-opioid receptor agonists.

Author information

1
Brain Imaging Section, NIDA Division of Intramural Research, Baltimore, MD 21224, USA.

Abstract

Several lines of evidence suggest an involvement of the mesolimbic dopamine (DA) system in the mediation of psychostimulant-induced sensitization. It is also apparent that endogenous opioid peptide systems can modulate the activity of this same DA system. Psychostimulant-induced alterations in opioid peptide gene expression have also been reported. In this review, evidence will be presented that demonstrates that the administration of kappa-opioid agonists can prevent the initiation of behavioral sensitization to cocaine and that such treatment is also effective in preventing alterations in mesolimbic DA neurotransmission that occur as a consequence of repeated cocaine administration. The putative role of opioid-DA interactions in the modulation of psychostimulant-induced sensitization will also be discussed.

PMID:
9218269
[Indexed for MEDLINE]

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