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Virology. 1997 Jul 7;233(2):440-2.

Roles of N-glycans with alpha2,6 as well as alpha2,3 linked sialic acid in infection by polyoma virus.

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Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA.


Specific glycosylation inhibitors were used to show that N-glycans, and not O-glycans or glycolipids, constitute the major class of receptors on 3T3 cells for polyoma virus. Sialic acid (SA)-specific lectins were used in attempts to confirm the expected SA linkage on N-linked glycans. A lectin specific for alpha2,6 linked SA, a non-receptor type, was slightly more effective in blocking infection than a lectin specific for alpha2,3 linked SA which corresponds to the known receptor specificity. Possible explanations are suggested for this unexpected result.

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