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Cell. 1997 Jun 27;89(7):1145-53.

Mitochondria are excitable organelles capable of generating and conveying electrical and calcium signals.

Author information

1
Department of Medical Biochemistry and Molecular Biology, Integrated Biological Systems Study Group, Victor Segalen-Bordeaux 2 University, France.

Abstract

We report Ca2(+)-induced release of Ca2+ from mitochondria (mCICR) dependent on transitory opening of the permeability transition pore (PTP) operating in a low conductance mode. The Ca2+ fluxes taking place during mCICR are a direct consequence of the mitochondrial depolarization spike (mDPS) caused by PTP opening. Both mDPS and mCICR can propagate from one mitochondrion to another in vitro, generating traveling depolarization and Ca2+ waves. Mitochondria thus appear to be excitable organelles capable of generating and conveying electrical and Ca2+ signals. In living cells, mDPS/mCICR is triggered during IP3-induced Ca2+ mobilization and results in the amplification of the Ca2+ signals primarily emitted from the endoplasmic reticulum.

PMID:
9215636
DOI:
10.1016/s0092-8674(00)80301-3
[Indexed for MEDLINE]
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