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J Clin Endocrinol Metab. 1997 Jul;82(7):2371-4.

Expression of estrogen receptor-beta in human breast tumors.

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Department of Biochemistry and Molecular Biology, University of Manitoba, Winnipeg, Canada.


The expression of a recently described novel estrogen receptor, ER-beta, was detected in several human breast tumor biopsy samples and several human breast epithelial cell lines using reverse transcription and polymerase chain reaction (RT-PCR) analysis. Cloning and sequencing of the PCR product from a breast tumor confirmed the identity of the sequence with that of the ER-beta mRNA previously reported in human testis. The expression of ER-beta was not correlated with that of ER-alpha, and both ER-alpha positive and ER-alpha negative cell lines expressed ER-beta mRNA. However, some breast tumors and some cell lines coexpress ER-beta and ER-alpha mRNA. Our data support a possible role for ER-beta in human breast cancer.

[Indexed for MEDLINE]

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