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Clin Neurol Neurosurg. 1997 May;99(2):87-90.

Familial spastic paraplegia: evidence for a fourth locus.

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  • 1Department of Neurology, Oudenryn Hospital, Utrecht, The Netherlands.


Autosomal dominant familial spastic paraparesis (AD-FSP) is a genetically heterogeneous disorder of the central nervous system characterized by a progressive spasticity of the legs. One gene causing AD-FSP (FSP1) has recently been mapped to chromosome 14q, another gene (FSP2) to chromosome 2p, and a third gene (FSP3) to chromosome 15q. We now report a large Dutch family with AD-FSP without linkage to any of these chromosomes, providing evidence for a fourth locus (FSP4).

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