Send to

Choose Destination
Med Pediatr Oncol. 1997 Sep;29(3):206-7.

Concomitant p53 mutation and MYCN amplification in neuroblastoma.

Author information

Research and Molecular Biology Division, Pró-Sangue Hemocentro de São Paulo Foundation, Brazil.


The MYCN oncogene is amplified in 20% of childhood neuroblastoma and is associated independently with poor prognosis. Alteration of the p53 tumor supressor gene, in contrast, occurs infrequently in these tumors. In this report, we described a 3-year-old girl with stage IV neuroblastoma. Molecular analysis revealed, both MYCN gene amplification and a point mutation of the p53 tumor supressor gene. To our knowledge, this is the first reported case of neuroblastoma with genetic alterations of both these genes.

Supplemental Content

Loading ...
Support Center