Send to

Choose Destination
Immunol Res. 1997;16(2):127-36.

C-reactive protein: structural biology, gene expression, and host defense function.

Author information

Department of Medicine, University of Alabama at Birmingham 35294, USA.


Over the past few years substantial insight was gained into the biology and biochemistry of human C-reactive protein (CRP). X-ray crystallography in conjunction with mutational analyses, generated the three-dimensional structure of the protein and indicated the topology and structure of ligand-binding sites. Using human CRP transgenic mice infected with Streptococcus pneumoniae, we obtained data that clearly established CRP as an important host defense molecule. Studies using the same mice revealed a previously unknown testosterone-dependence of constitutive expression of human CRP. In this article we provide a brief overview of these recent findings.

[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center