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Leukemia. 1997 Apr;11 Suppl 3:179-82.

Rapid induction of B-cell lymphomas by avian leukosis virus.

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Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA.


Avian leukosis viruses (ALVs) that induce rapid B-cell lymphomas integrate into the c-myb gene and produce an ALV-myb read-through RNA, which is spliced to produce a truncated Myb protein. The genetic determinants of such recombinant ALVs have been mapped to a 42-nt deletion within the gag gene. This deletion increases splicing efficiency since it is located within a negative regulator of splicing. We propose that the deletion leads to increased production of Myb protein by increasing splicing of an ALV-myb pre-mRNA.

[Indexed for MEDLINE]

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