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Ann Allergy Asthma Immunol. 1997 Jun;78(6):598-601.

Intranasal budesonide spray as an adjunct to oral antibiotic therapy for acute sinusitis in children.

Author information

1
Marmara University Hospital, Department of Pediatrics Istanbul, Turkey.

Abstract

BACKGROUND:

The role of topical corticosteroids in the treatment of acute sinusitis has not been established in children.

OBJECTIVE:

An attempt was made to determine the impact of topical corticosteroids as an adjunct to antibiotic treatment in the management of childhood sinusitis.

METHODS:

In a double-blind, placebo-controlled study, 151 children with sinusitis were recruited from a general pediatric outpatient clinic and 89 completed a 3-week trial. Treatment consisted of amoxicillin-clavulanate potassium, 40 mg/kg/d tid, combined with bid nasal spray of either budesonide, 50 micrograms, to each nostril (n = 43) or placebo )n = 46_ for 3 weeks. Patients maintained daily symptom cards throughout the study and were examined by the same physician each week.

RESULTS:

Clinical symptoms and signs decreased significantly in both treatment groups in comparison to baseline (P < .01). We detected a significant improvement in the scores of the cough and nasal discharge at the end of second week in the budesonide group when compared with placebo (P < .05). Friedman nonparametric repeated measures ANOVA test revealed a significant decrease in the total weekly scores of cough during the second week of budesonide treatment (P < .001) in contrast to continuous decline during the second and third weeks in the placebo group (P < .001 and P < .05, respectively). While the nasal discharge score decreased significantly during the second week in the budesonide group (P < .01), no significant effect on the nasal discharge score was observed in the placebo group.

CONCLUSION:

These data suggest that topical corticosteroids may be a useful ancillary treatment to antibiotics in childhood sinusitis and effective in reducing the cough and nasal discharge earlier in the course of acute sinusitis.

PMID:
9207726
DOI:
10.1016/S1081-1206(10)63223-1
[Indexed for MEDLINE]

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