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Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7612-6.

Aggregation and disaggregation of senile plaques in Alzheimer disease.

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1
Center for Polymer Studies and Department of Physics, Boston University, Boston, MA 02215, USA.

Abstract

We quantitatively analyzed, using laser scanning confocal microscopy, the three-dimensional structure of individual senile plaques in Alzheimer disease. We carried out the quantitative analysis using statistical methods to gain insights about the processes that govern Abeta peptide deposition. Our results show that plaques are complex porous structures with characteristic pore sizes. We interpret plaque morphology in the context of a new dynamical model based on competing aggregation and disaggregation processes in kinetic steady-state equilibrium with an additional diffusion process allowing Abeta deposits to diffuse over the surface of plaques.

PMID:
9207140
PMCID:
PMC23870
[Indexed for MEDLINE]
Free PMC Article
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