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Radiology. 1997 Jul;204(1):263-8.

In vivo target-specific delivery of macromolecular agents with MR-guided focused ultrasound.

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Department of Radiology, Stanford University School of Medicine, CA 94305, USA.


Magnetic resonance (MR) images in rabbit muscle were used to select a target region for application of pulsed-focused ultrasound. Liposomes encapsulating gadopentetate dimeglumine, an MR-detectable model representing pharmaceutical agents, were then injected intravenously. Focal enhancement on T1-weighted images, representing gadolinium-liposome accumulation, occurred in the pulsed-focused-ultrasound focal zone. Therefore, MR-guided pulsed-focused ultrasound targeted the delivery of macromolecular pharmaceutical agents within tissues.

[Indexed for MEDLINE]

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