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Trends Biochem Sci. 1997 Jun;22(6):217-24.

Tailoring cAMP-signalling responses through isoform multiplicity.

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Division of Biochemistry and Molecular Biology, University of Glasgow, Scotland, UK.


Multiple forms of cAMP phosphodiesterases (PDE), adenylate cyclase and protein kinase A (PKA) allow cells to tailor the responsiveness of the cAMP-signalling system and to allow for its dynamic adjustment. Multiple forms of these enzymes confer spatial and temporal characteristics on cAMP signalling so as to affect compartmentalised responses within a single cell type. The ability to breach the PKA activation threshold can depend upon either or both the activation of adenylate cyclase and inhibition of specific PDE isoforms.

[Indexed for MEDLINE]

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