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Trends Biochem Sci. 1997 Jun;22(6):207-10.

Redox signal transduction via iron-sulfur clusters in the SoxR transcription activator.

Author information

1
Department of Molecular and Cellular Toxicology, Harvard School of Public Health, Boston, MA 02115, USA.

Abstract

Protein iron-sulfur (FeS) centers have recently been implicated in the regulation of gene expression. In the redox-sensing SoxR protein, the oxidation state of [2Fe-2S] centers controls its activity as a transcription activator independent of DNA-binding ability. Thus, FeS centers allosterically link cellular oxidative stress to the expression of defense genes.

PMID:
9204707
DOI:
10.1016/s0968-0004(97)01068-2
[Indexed for MEDLINE]

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