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Curr Opin Struct Biol. 1997 Jun;7(3):416-21.

Three-dimensional domain duplication, swapping and stealing.

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Division of Mathematical Biology, National Institute for Medical Research, Mill Hill, London, UK.


Examination of multidomain and/or multimeric protein structures can reveal evolutionary paths to a more complex 3D organization. Over the past few years, proteins have been shown to evolve while preserving mutual domain organization and interfaces. The recent advances in understanding domain reorganization and mobility highlight the versatility and efficiency of protein structural evolution.

[Indexed for MEDLINE]

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