Format

Send to

Choose Destination
Curr Opin Immunol. 1997 Jun;9(3):358-64.

Pathways leading to cell death in T cells.

Author information

1
Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, Box 295, New York, NY 10021, USA. wongb@rockvax.rockefeller.edu

Abstract

Antigen-induced apoptosis of T cells is a highly regulated process which plays a key role in the elimination of self-reactive T cells and, thus, in the prevention of autoimmunity. It has recently become apparent that members of the tumor necrosis factor (TNF) and TNF receptor (TNFR) superfamily regulate antigen-induced T-cell death. Studies characterizing genes which control TNF/TNFR superfamily expression and how TNF/TNFR signal transducers activate cell death machinery, such as caspases, have begun to reveal the molecular control of antigen-induced T-cell death.

PMID:
9203409
DOI:
10.1016/s0952-7915(97)80082-9
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center