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J Pediatr. 1997 Jun;130(6):885-9.

Occurrence of myeloproliferative disorder in patients with Noonan syndrome.

Author information

1
Department of Pediatrics, Bicêtre Hospital, Le Kremlin Bicêtre, France.

Abstract

We report four cases of Noonan syndrome associated with chronic myelomonocytic leukemia in childhood. These children shared some hematologic features: thrombocytopenia, splenomegaly in the first months of life, occurrence of chronic myelomonocytic leukemia without abnormalities of the initial bone marrow karyotype, and, in three cases, improvement of the hematologic disease. A common pathophysiologic process in such patients is suggested.

PMID:
9202609
DOI:
10.1016/s0022-3476(97)70273-7
[Indexed for MEDLINE]

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