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Nihon Rinsho. 1997 Jun;55(6):1512-8.

[T cell vaccination--induction of anti-idiotypic immune response against TCR and shift of Th1/Th2 balance].

[Article in Japanese]

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Department of Clinical Investigation, Hara-doi Hospital.


T cell vaccination, originally contrived and coinned by I.R. Cohen is the injection of autoimmune pathogenic T cell line/clone or T cell receptor peptides in an attempt to induce anti-idiotypic regulation to treat autoimmune disease. Establishment of many T cell lines/clones from various autoimmune animal model and successful injection of these cells as T cell vaccine have been reported, although the exact mechanism for vaccination effect has not been elucidated. However, recent reports suggest that not the clonal deletion or anergy but the shift of Th1/Th2 balance of disease-related T lymphocytes may be involved in the effect of vaccination.

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