Format

Send to

Choose Destination
Scand J Gastroenterol. 1997 Jun;32(6):535-40.

Eradication of Helicobacter pylori affects symptoms in non-ulcer dyspepsia.

Author information

1
Dept. of Gastroenterology, Meath/Adelaide Hospitals, Trinity College, Dublin, Ireland.

Abstract

BACKGROUND:

The relationship between Helicobacter pylori infection and non-ulcer dyspepsia is controversial.

METHODS:

In a prospective, long-term, double-blind study we randomized 100 patients with non-ulcer dyspepsia and H. pylori infection to receive either of two treatment regimens: 1) bismuth-based triple therapy (n = 50) or 2) bismuth + placebo (n = 50).

RESULTS:

Triple therapy: subjects who became H. pylori-negative (n = 42) showed a significant symptomatic response when interviewed at 8 weeks, 6 months, and 1 year (P < 0.01). This improvement was evident in the 'ulcer-like' dyspepsia group at all times (P < 0.01) but in the 'reflux-like' and 'motility-like' groups at 6 months only (P < 0.01). Those who remained H. pylori-positive showed no decrease in symptoms at 8 weeks, 6 months, and 1 year. Bismuth-placebo therapy: subjects who became H. pylori-negative (n = 7) showed an improvement in symptoms at 8 weeks, 6 months, and 1 year. Those who continued to harbour the infection after treatment (n = 42) showed an insignificant improvement in the motility and non-specific groups only.

CONCLUSION:

This study shows that eradication of H. pylori results in a significant long-term reduction in symptoms of non-ulcer dyspepsia.

Comment in

PMID:
9200283
DOI:
10.3109/00365529709025095
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Taylor & Francis
Loading ...
Support Center