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Thromb Haemost. 1997 Jul;78(1):310-4.

The role of leukocyte and endothelial adhesion molecules in ischemia-reperfusion injury.

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Department of Anesthesia & Critical Care, University of Washington, Children's Hospital & Medical Center, Seattle, USA.


Reperfusion of ischemic tissue is associated with an acute inflammatory response that may further exacerbate vascular and tissue damage. Compelling evidence from a variety of animal models indicates that neutrophils are the principle effector cells of the reperfusion injury and that blockade of neutrophil adhesion to endothelium attenuates ischemia-reperfusion injury. "Anti-adhesion" therapy may represent a new approach to treatment of the many diverse clinical disorders in which ischemia-reperfusion occurs.

[Indexed for MEDLINE]

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