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Chem Biol. 1997 Apr;4(4):259-67.

Understanding enzymic catalysis: the importance of short, strong hydrogen bonds.

Author information

  • 1Department of Biochemistry, University of Illinois, 600 South Mathews Avenue, Urbana, IL 61801, USA. j-gerlt@uiuc.edu

Abstract

We have proposed previously that short, strong hydrogen bonds exist in enzyme active sites and that they are important in explaining enzymic rate enhancements. Here, we defend this proposal and provide evidence for likely changes of hydrogen bond strengths during enzymic catalysis.

PMID:
9195866
[PubMed - indexed for MEDLINE]
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