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Hosp Pract (1995). 1997 Jun 15;32(6):81-2, 85, 88-92.

Homocysteine, oxidative stress, and vascular disease.

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Evans Department of Medicine, Whitaker Cardiovascular Institute, Boston University School of Medicine, USA.


First recognized in patients with rare inborn errors of metabolism, the association of elevated plasma homocysteine concentrations with atherosclerosis and thrombosis now seems relevant to the general population as well. The mechanism of injury appears to involve oxidative damage to endothelial cells. Vitamin supplementation can normalize homocysteine levels and may lower the incidence of atherothrombotic vascular disease.

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[Indexed for MEDLINE]

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