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Calcif Tissue Int. 1997 Jul;61(1):59-61.

Inhibition of matrix metalloproteinase-1 by dichloromethylene bisphosphonate (clodronate).

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Department of Oral and Maxillofacial Surgery, Institute of Dentistry, University of Helsinki, P.O. Bos 41 (Mannerheimintie 172) FIN-00014, Helsinki, Finland.


Interstitial collagenase present in human jaw cyst extract and purified human fibroblast-type collagenase (MMP-1) were both efficiently inhibited in vitro by clodronate, an osteoactive, antiresorptive bisphosphonate. The IC50 of clodronate to inhibit MMP-1 is 150 microM. These findings suggest an extended and hitherto undescribed properties for clodronate/biphosphonates in prevention and treatment of tissue degradation in both bone and soft tissue destructive diseases.

[Indexed for MEDLINE]

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